Plasma concentrations of transforming growth factor beta 1 in non-progressive HIV-1 infection correlates with markers of disease progression.
Identifieur interne : 000164 ( Main/Exploration ); précédent : 000163; suivant : 000165Plasma concentrations of transforming growth factor beta 1 in non-progressive HIV-1 infection correlates with markers of disease progression.
Auteurs : Edward K. Maina [Kenya] ; C Z Abana [Ghana] ; E A Bukusi [Kenya] ; M. Sedegah [États-Unis] ; M. Lartey [Ghana] ; W K Ampofo [Ghana]Source :
- Cytokine [ 1096-0023 ] ; 2016.
Descripteurs français
- KwdFr :
- ARN viral (génétique), ARN viral (sang), Adulte, Adulte d'âge moyen, Antirétroviraux (usage thérapeutique), Cytokines (sang), Facteur de croissance transformant bêta-1 (sang), Femelle, Humains, Infections à VIH (sang), Infections à VIH (traitement médicamenteux), Infections à VIH (virologie), Jeune adulte, Lymphocytes T CD4+ (métabolisme), Lymphocytes T CD8+ (métabolisme), Lymphocytes auxiliaires Th1 (métabolisme), Lymphocytes auxiliaires Th2 (métabolisme), Mâle, Numération des lymphocytes, Rapport CD4-CD8, Sujet âgé, VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (physiologie), Études transversales, Évolution de la maladie.
- MESH :
- génétique : ARN viral, VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- métabolisme : Lymphocytes T CD4+, Lymphocytes T CD8+, Lymphocytes auxiliaires Th1, Lymphocytes auxiliaires Th2.
- physiologie : VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- sang : ARN viral, Cytokines, Facteur de croissance transformant bêta-1, Infections à VIH.
- traitement médicamenteux : Infections à VIH.
- usage thérapeutique : Antirétroviraux.
- virologie : Infections à VIH.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Jeune adulte, Mâle, Numération des lymphocytes, Rapport CD4-CD8, Sujet âgé, VIH-1 (Virus de l'Immunodéficience Humaine de type 1), Études transversales, Évolution de la maladie.
English descriptors
- KwdEn :
- Adult, Aged, Anti-Retroviral Agents (therapeutic use), CD4-CD8 Ratio, CD4-Positive T-Lymphocytes (metabolism), CD8-Positive T-Lymphocytes (metabolism), Cross-Sectional Studies, Cytokines (blood), Disease Progression, Female, HIV Infections (blood), HIV Infections (drug therapy), HIV Infections (virology), HIV-1 (drug effects), HIV-1 (genetics), HIV-1 (physiology), Humans, Lymphocyte Count, Male, Middle Aged, RNA, Viral (blood), RNA, Viral (genetics), Th1 Cells (metabolism), Th2 Cells (metabolism), Transforming Growth Factor beta1 (blood), Young Adult.
- MESH :
- chemical , blood : Cytokines, RNA, Viral, Transforming Growth Factor beta1.
- chemical , genetics : RNA, Viral.
- chemical , therapeutic use : Anti-Retroviral Agents.
- blood : HIV Infections.
- drug effects : HIV-1.
- drug therapy : HIV Infections.
- genetics : HIV-1.
- metabolism : CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Th1 Cells, Th2 Cells.
- physiology : HIV-1.
- virology : HIV Infections.
- Adult, Aged, CD4-CD8 Ratio, Cross-Sectional Studies, Disease Progression, Female, Humans, Lymphocyte Count, Male, Middle Aged, Young Adult.
Abstract
The human immunodeficiency virus (HIV) infection shows variable rate of disease progression. The underlying biological and molecular mechanisms involved in determining progression of HIV infection are not fully understood. The aims of this study were to determine plasma concentrations of active TGF β 1, Th1 and Th2 cytokines in patients with non-progressive and those with progressive HIV-1 infection, as well as to determine if there is an association of these cytokines to disease progression. In a cross-sectional study of 61 HIV-1 infected individuals categorized according to disease progression as having non-progressive HIV-1 infection (n=14) and progressive infection (n=47), plasma levels of active TGF β 1, INF-γ, TNF-α, IL-10, IL-1β, IL-12p70 and IL-13 were compared with HIV uninfected healthy controls (n=12). Plasma concentration of these cytokines was measured using a highly sensitive luminex200 XMAP assay. Pearson correlation test was used to assess the correlation of cytokines with CD4+ and CD8+ T cells, CD4:CD8 ratio and plasma HIV-1 RNA in the different study groups. Plasma concentrations of TGF β 1 and IL-10 were significantly decreased while IL-1β, IL-12p70 and TNF-α were increased in patients with non-progressive HIV-1 infection compared to patients with progressive infection. Plasma levels of TGF β 1 and IL-10 showed an inverse correlation with CD8+ T cell counts and CD4:CD8 ratios in patients with non-progressive HIV-1 infection, while plasma HIV-1 RNA positively correlated with CD4+ T cell counts. Plasma levels of TNF-α, IL-1β, IL-12p70 and IL-13 positively correlated with CD4+ T cell counts and inversely correlated with plasma HIV-1 RNA, CD8+ T cell count and CD4:CD8 ratio in patients with non-progressive infection. The correlation of cytokines to the state of T-lymphocyte and plasma HIV-1 RNA found in this study may provide insight into the role of cytokines in both progressive and non-progressive HIV-1 infection. Additionally, these findings may have implications for systemic cytokine-based therapies in HIV-1 infection.
DOI: 10.1016/j.cyto.2016.02.009
PubMed: 26986868
Affiliations:
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Maina</name><affiliation wicri:level="4"><nlm:affiliation>Department of Virology, Noguchi Memorial Institute for Medical Research, College of Health Sciences (CHS), University of Ghana, Ghana; Centre for Microbiology Research, Kenya Medical Research Institute, Kenya. 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Lartey</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, School of Medicine & Dentistry, CHS, University of Ghana, Ghana.</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>Department of Medicine, School of Medicine & Dentistry, CHS, University of Ghana</wicri:regionArea><placeName><settlement type="city">Accra</settlement><settlement type="town">Legon (Ghana)</settlement><region type="region">Région du Grand Accra</region></placeName><orgName type="university">Université du Ghana</orgName></affiliation></author><author><name sortKey="Ampofo, W K" sort="Ampofo, W K" uniqKey="Ampofo W" first="W K" last="Ampofo">W K Ampofo</name><affiliation wicri:level="4"><nlm:affiliation>Department of Virology, Noguchi Memorial Institute for Medical Research, College of Health Sciences (CHS), University of Ghana, Ghana.</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>Department of Virology, Noguchi Memorial Institute for Medical 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therapy)</term><term>HIV Infections (virology)</term><term>HIV-1 (drug effects)</term><term>HIV-1 (genetics)</term><term>HIV-1 (physiology)</term><term>Humans</term><term>Lymphocyte Count</term><term>Male</term><term>Middle Aged</term><term>RNA, Viral (blood)</term><term>RNA, Viral (genetics)</term><term>Th1 Cells (metabolism)</term><term>Th2 Cells (metabolism)</term><term>Transforming Growth Factor beta1 (blood)</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (génétique)</term><term>ARN viral (sang)</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Antirétroviraux (usage thérapeutique)</term><term>Cytokines (sang)</term><term>Facteur de croissance transformant bêta-1 (sang)</term><term>Femelle</term><term>Humains</term><term>Infections à VIH (sang)</term><term>Infections à VIH (traitement médicamenteux)</term><term>Infections à VIH (virologie)</term><term>Jeune adulte</term><term>Lymphocytes T CD4+ (métabolisme)</term><term>Lymphocytes T CD8+ (métabolisme)</term><term>Lymphocytes auxiliaires Th1 (métabolisme)</term><term>Lymphocytes auxiliaires Th2 (métabolisme)</term><term>Mâle</term><term>Numération des lymphocytes</term><term>Rapport CD4-CD8</term><term>Sujet âgé</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) ()</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique)</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (physiologie)</term><term>Études transversales</term><term>Évolution de la maladie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Cytokines</term><term>RNA, Viral</term><term>Transforming Growth Factor beta1</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Retroviral Agents</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>HIV-1</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>HIV-1</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN viral</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>CD4-Positive T-Lymphocytes</term><term>CD8-Positive T-Lymphocytes</term><term>Th1 Cells</term><term>Th2 Cells</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Lymphocytes T CD4+</term><term>Lymphocytes T CD8+</term><term>Lymphocytes auxiliaires Th1</term><term>Lymphocytes auxiliaires Th2</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>HIV-1</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>ARN viral</term><term>Cytokines</term><term>Facteur de croissance transformant bêta-1</term><term>Infections à VIH</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à VIH</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antirétroviraux</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à VIH</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>CD4-CD8 Ratio</term><term>Cross-Sectional Studies</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Lymphocyte Count</term><term>Male</term><term>Middle Aged</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Numération des lymphocytes</term><term>Rapport CD4-CD8</term><term>Sujet âgé</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term><term>Études transversales</term><term>Évolution de la maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The human immunodeficiency virus (HIV) infection shows variable rate of disease progression. The underlying biological and molecular mechanisms involved in determining progression of HIV infection are not fully understood. The aims of this study were to determine plasma concentrations of active TGF β 1, Th1 and Th2 cytokines in patients with non-progressive and those with progressive HIV-1 infection, as well as to determine if there is an association of these cytokines to disease progression. In a cross-sectional study of 61 HIV-1 infected individuals categorized according to disease progression as having non-progressive HIV-1 infection (n=14) and progressive infection (n=47), plasma levels of active TGF β 1, INF-γ, TNF-α, IL-10, IL-1β, IL-12p70 and IL-13 were compared with HIV uninfected healthy controls (n=12). Plasma concentration of these cytokines was measured using a highly sensitive luminex200 XMAP assay. Pearson correlation test was used to assess the correlation of cytokines with CD4+ and CD8+ T cells, CD4:CD8 ratio and plasma HIV-1 RNA in the different study groups. Plasma concentrations of TGF β 1 and IL-10 were significantly decreased while IL-1β, IL-12p70 and TNF-α were increased in patients with non-progressive HIV-1 infection compared to patients with progressive infection. Plasma levels of TGF β 1 and IL-10 showed an inverse correlation with CD8+ T cell counts and CD4:CD8 ratios in patients with non-progressive HIV-1 infection, while plasma HIV-1 RNA positively correlated with CD4+ T cell counts. Plasma levels of TNF-α, IL-1β, IL-12p70 and IL-13 positively correlated with CD4+ T cell counts and inversely correlated with plasma HIV-1 RNA, CD8+ T cell count and CD4:CD8 ratio in patients with non-progressive infection. The correlation of cytokines to the state of T-lymphocyte and plasma HIV-1 RNA found in this study may provide insight into the role of cytokines in both progressive and non-progressive HIV-1 infection. Additionally, these findings may have implications for systemic cytokine-based therapies in HIV-1 infection.</div></front></TEI><affiliations><list><country><li>Ghana</li><li>Kenya</li><li>États-Unis</li></country><region><li>Région du Grand Accra</li></region><settlement><li>Accra</li><li>Legon (Ghana)</li></settlement><orgName><li>Université du Ghana</li></orgName></list><tree><country name="Kenya"><region name="Région du Grand Accra"><name sortKey="Maina, Edward K" sort="Maina, Edward K" uniqKey="Maina E" first="Edward K" last="Maina">Edward K. Maina</name></region><name sortKey="Bukusi, E A" sort="Bukusi, E A" uniqKey="Bukusi E" first="E A" last="Bukusi">E A Bukusi</name></country><country name="Ghana"><region name="Région du Grand Accra"><name sortKey="Abana, C Z" sort="Abana, C Z" uniqKey="Abana C" first="C Z" last="Abana">C Z Abana</name></region><name sortKey="Ampofo, W K" sort="Ampofo, W K" uniqKey="Ampofo W" first="W K" last="Ampofo">W K Ampofo</name><name sortKey="Lartey, M" sort="Lartey, M" uniqKey="Lartey M" first="M" last="Lartey">M. Lartey</name></country><country name="États-Unis"><noRegion><name sortKey="Sedegah, M" sort="Sedegah, M" uniqKey="Sedegah M" first="M" last="Sedegah">M. Sedegah</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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